PROVIDEAN REPRODUCTIVA
VACCINE FOR THE PREVENTION OF BOVINE REPRODUCTIVE DISEASES
SYNDROME: REPRODUCTIVE


Each 0.1 ml dose contains: Purified protein derivative of avian tuberculin from culture of Mycobacterium avium subsp. avium, strain D4ER. 2500 IU/dose Excipients q.s.
In all species apply: 0.1 ml of Avian Tuberculin PPD 2500 containing 2500 IU/dose ( ≥75% and ≤133%) intradermally.
Avian Tuberculin PPD 2500 is a diagnostic reagent to be used for in vivo identification of animals that have been exposed to Mycobacterium species causing tuberculosis.
It should always be used in combination with Bovine Tuberculin PPD in the comparative test (Bovine Tuberculin PPD – Avian Tuberculin PPD) in cattle, sheep, swine and goats. For intradermal injection, the needle should be inserted into the skin in such a way as to ensure intradermal administration of PPD Tuberculin with the beveled edge facing outward and with the graduated syringe loaded with PPD Tuberculin.
Cattle
Injection site selection. The injection site for the cattle is in the neck for the comparative cervical test. In animals that have inflammation or unrelated lumps close to the recommended injection site, the tuberculin should be injected on the opposite side of the animal. Cervical site (double injection: comparative test): Approved injection sites are located at the boundary between the anterior third and the middle third of either side of the neck. To establish whether cattle are infected with Mycobacterium bovis or other non-bovine strains of mycobacteria, the comparative test is performed by simultaneously inoculating bovine PPD and avian PPD into the neck muscles (neck’s injection triangle). Results (reaction) are expressed as the difference in skin thickness (mm) between the pre- and post-skin test readings. Avian PPD was chosen as a term of comparison, in principle, to rule out Mycobacterium avium infection and also because this bacterium has common antigenic relationships with the species Mycobacterium avium subsp. paratuberculosis (Paratuberculosis) and with others responsible for cross-reactions to Bovine Tuberculin. In adult animals the highest inoculation site is approximately 10 cm below the nuchal ligament for Avian PPD. The lowest site should be approximately 12 cm from the upper site where Bovine PPD will be inoculated, on a line parallel to the shoulder line. In young animals where there is insufficient space to inject both PPD tuberculin on the same side of the neck, they should be injected in the center of the middle third on each side of the neck, respectively. In animals with unrelated inflammation or lumps close to the injection site(s), the PPD tuberculin should be injected in the middle third of each side of the neck, respectively.
Sheep
They are also susceptible to infection with M. avium subsp paratuberculosis, which causes paratuberculosis disease, therefore the axillary comparative test with bovine PPD and avian PPD tuberculin should be used. Intradermally inject (0.1 ml) bovine tuberculin in the right axilla and (0.1 ml) avian tuberculin in the left axilla, with two (2) different syringes. The reading should be performed (72) hours after administration by palpation and measured with a caliper.
Swine
Both bovine PPD and avian PPD tuberculin should be used. Inject (0.1 ml) of bovine tuberculin and (0.1 ml) of avian tuberculin, with two (2) different syringes. The intradermal injection site is the skin at the base of the ear. If this region is scarred or otherwise defective, testing can be done on the lips of the vulva of the sow or at the junction between the male’s rectal mucosa and skin. Bovine tuberculin is injected on the right side and avian tuberculin on the left. The reading is performed after (48) hours, and any tissue reaction verified by palpation is classified as reactive, and it should be noted whether it is due to bovine or avian tuberculin.
Goats
It should be applied on the neck for the comparative cervical test. The technique of application, reading and interpretation is similar to that of bovines.
Vials of 2 ml containing 20 doses of 0.1 ml.
Treatment guide in case of autoinoculation.
GuÃa de tratamiento en caso de autoinoculación.
Keep out of the reach of children. In case of accident with the product, contact the National Poison Center (In Argentina Telephone: 0800-333-0160). Do not subject animals to herding or excessive work before and after the vaccination. Do not administer to parasitized, malnourished, fatigued, or feverish animals, or animals on antibiotic and/or corticosteroid treatment.
Administer this product under veterinary supervision. The product may generate a slight local reaction at the application site that disappears progressively. In isolated cases, this vaccine may produce anaphylactic shock, in which case administer epinephrine at 1‰.
Between 2 and 8º C. Do not freeze. Do not expose to heat or sunlight
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We are a biotechnology company with more than twenty years of experience in the development, production and global commercialization of new vaccines and immunotherapies to protect animal life and productivity.
We are a biotechnology company with more than twenty years of experience in the development, production and global commercialization of new vaccines and immunotherapies to protect animal life and productivity.